ME/CFS: Did peptides help?

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SoreTodayStrongTomor

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Hi everyone,

I have ME/CFS with PEM and have been reading about mitochondrial problems and energy issues in ME/CFS.

I know these are not proven treatments, but I wanted to ask if anyone has tried:

  • SS-31
  • MOTS-c
  • Thymosin alpha-1
Did any of them help with:

  • PEM / crashes after activity?
  • Better exercise tolerance or less crashing?
  • Delayed PEM, not just everyday fatigue?
Did anyone have side effects or get worse?

Also, did these only help after treating things like POTS, dysautonomia, sleep problems, or MCAS?

I’m trying to understand real experiences and separate them from online hype.

Thanks.
 
I have a form of CF. But it's not the typical one 'ya read about online.

ME:

62M former athlete

Hashimoto's thyroid failure

Secondary Adrenal Insufficency (severe and life threatening)

Mixed Connective Tissue Disease (RNP antibodies, it's akin to Lupus)

Possible Myasthenia Gravis (muscles non responsive)

I don't have the classic pain symptoms of CFS. Nothing hurts.

NO, the bottom line is that SS31, MOTS-C, BPC157 TB5/400, GHK-Cu and Retatrutide have not helped my severe fatigue, exercise intolerance and subsequent week long crashes after energy expenditure. I've just experienced more than a month of fatigue so severe I can't keep my eyes open. I fall asleep constantly and wife wakes me up. Dog checks for signs of life. It's abject torture. So the peptides I've tried are no cure, no significant help with the fatigue and maybe it is time to try other peptides.

HOWEVER, Retatrutide has been a godsend in other ways. Epic weight loss, incredible inflammation reduction and stronger metabolism, which means I can eat without worry, and fuel my activities a bit better. The required starvation before my Reta use left me with insufficient calories to perform work.

SS31 and MOTS-C do not provide any feeling of relief for me. But again, there is a change there. When I walk the dog around the block I can if needed jog a very short distance home. Takes massive effort, but I've not been able to do that in years. Wiped out afterwards, but I can do it.

I continue to search for solutions. But my health remains in slow decline.
 
ME/CFS and Long Covid sufferer.

Retatrutide so far has been of some relief, gives me a bit more energy. Can't speak to the others I haven't tried them yet.
 
A little late to the party but I was wondering the same, a bit discouraged by the lack of responses 🙁

My partner is in a very similar situation as you in terms of symptoms, after the C0vid vaccines they developed a form of seronegative spondyloarthritis (so no autoantibodies). On top of PEM they have general fatigue, issues with sleep, sleep problems, entheses inflammation and so on. They're so sick of it! I was hoping to find ideas here, but no luck either so far.

I'll write updates here in case we find something that could help, best of luck <3
 
I've been researching SS31 but haven't taken the plunge yet because there is so little about it compared to the GLPs and from what I've read about it, it's just 'we think maybe ME is caused by something mitochondrial, and SS31 helps people who are confirmed to have mitochondrial issues so it should help if we're right about that, but will do nothing if that's not the case'

Sorry that's not a decent response, but I'm commenting because I'm interested in seeing what others have to say and I want to leave this as evidence there are at least some people looking to research this personally!
 
The one I am most interested in trying is TA1. The reason is there is quite a lot of measured issues with T cells in both conditions and I have measured that misbalance in myself. TA1 has good evidence behind it for rebalancing these issues. What has got in the way is one delivery of bad product and difficulty in being able to find it in stock and finding others to share the cost of testing it with.

Along the same angle of immune system LL-37 and also VIP seem potentially promising as well. Same issue with these in availability and testing costs.

SS-31 potentially is interesting for mito repair as might MOTS-C but I think to think these are not the primary issue but downstream of other aspects and so anything you do here is likely going to wear off quite quickly.

I can't speak to any of this working, I haven't worked out the logistics of getting a tested product in my hands without spending a small fortune.
 
BrightCandle said:


The one I am most interested in trying is TA1. The reason is there is quite a lot of measured issues with T cells in both conditions and I have measured that misbalance in myself. TA1 has good evidence behind it for rebalancing these issues. What has got in the way is one delivery of bad product and difficulty in being able to find it in stock and finding others to share the cost of testing it with.

Along the same angle of immune system LL-37 and also VIP seem potentially promising as well. Same issue with these in availability and testing costs.

SS-31 potentially is interesting for mito repair as might MOTS-C but I think to think these are not the primary issue but downstream of other aspects and so anything you do here is likely going to wear off quite quickly.

I can't speak to any of this working, I haven't worked out the logistics of getting a tested product in my hands without spending a small fortune.

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I have been on tirz for 18 months but have only recently been diagnosed with ME, essentially because after 12+ years there is nothing else it could possibly be. I have basically been told there is nothing they can do to help, and it was through this forum I realised there may be things that I could try myself and potentially gain back some quality of life.

I've been focussing on SS-31 while researching because it seems like it is slightly more readily available and has seen some success in trials with people who have other mitochondrial disorders, but I am definitely going to read up on the others you have mentioned here and hope that they become more accessible as more evidence emerges.
 
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