Visceral fat and inflammation?

PeptideConsumer

PeptideConsumer

New member
Joined
Aug 20, 2026
Messages
13
Reaction score
0
Location
Imported archive
Up to 2018 and early 2019, I was in good to very good shape.

Active every day, no body fat percentage, no health problems of any kind.

End of 2019 moving into the end of 2020, I pretty much stopped exercises, lost any definition to abdominal muscles (got fat), lost muscle definition in general;

And for the first time I noticed intolerances to certain chemicals emerged. Melanotan 2 was the first to give me side effects.

I modified my diet slightly and lost some weight, but didn't recommence exercise.

But over all my diet still consisted of lots of sugar and refined carbs.

Tinnitus emerged at the start of 2022, along with sinusitis, and dermatitis.

Decreased tolerance to other chemicals followed to the point of having to discontinue melanotan entirely as it was now, for the first time, affecting my mood.

I had used it for years when in good shape with zero side effects.

As of the last couple months I've started to get back in shape. Now, I've always looked okay, but my mid section in particular is just padded.

I assume that's visceral fat, the insidious kind, and the one notorious for contributing to inflammation.

Visceral fat is deep belly fat that wraps around your internal organs like the liver, pancreas, and intestines. Having too much of it raises your risk for serious health problems like type 2 diabetes and heart disease, even if you look thin on the outside. [1, 2, 3]

Click to expand...
Click to expand...

What is Visceral Fat?

    • Hidden fat: It sits deep inside your belly, unlike subcutaneous fat which you can pinch right under your skin.
    • Active tissue: It acts like an active organ in your body, releasing harmful chemicals and hormones that cause inflammation and insulin resistance. [1, 2]
Health Risks

    • Type 2 diabetes: Stops your body from using insulin the right way.
    • Heart disease: Raises your blood pressure and blood cholesterol, which can block your blood vessels.
    • Other issues: Linked to liver disease and certain types of cancer. [1, 2, 3]
Main Causes

    • Bad diet: Eating lots of sugar, refined carbs, and processed foods.
    • No exercise: Sitting too much and not burning enough energy.
    • High stress: Stress makes your body release a hormone called cortisol, which tells your body to store fat in the belly.
    • Poor sleep and alcohol: Not sleeping well or drinking too much alcohol. [1, 2, 3, 4]

Click to expand...
Click to expand...

I'm curious whether, as I progress with getting back in good physical health via return to regular exercise, inflammatory symptoms will subside.
 
Your screen name says PeptideConsumer yet you don't mention any dosing.

Are you pinning any 'tides? Several of your symptoms can be caused by some 'tides. Your age and overall health might be pertinent as well, if you care to share.
 
PeptideConsumer said:


I'm curious whether, as I progress with getting back in good physical health via return to regular exercise, inflammatory symptoms will subside.

Click to expand...
Click to expand...

Yes, GLP-1 RAs reduce inflammation, through two overlapping routes. Part of it is just losing visceral fat, which is metabolically active and pro-inflammatory. But there's also a direct, weight-independent effect via GLP-1 receptors on immune cells and vascular tissue, plus central signaling that lowers systemic inflammatory tone.


JCI - Antiinflammatory actions of glucagon-like peptide-1–based therapies beyond metabolic benefits
 
PeptideConsumer said:


As of the last couple months I've started to get back in shape. Now, I've always looked okay, but my mid section in particular is just padded.

I assume that's visceral fat, the insidious kind, and the one notorious for contributing to inflammation.

Click to expand...
Click to expand...

If you can pinch it, it’s subcutaneous fat, making you look padded. Visceral fat is behind the abdominal wall, making you look bloated, but it pushes the muscles out vs padding them.
 
deluge said:


Your screen name says PeptideConsumer yet you don't mention any dosing.

Are you pinning any 'tides? Several of your symptoms can be caused by some 'tides. Your age and overall health might be pertinent as well, if you care to share.

Click to expand...
Click to expand...
Melanotan.

I've cycled BPC 157 and the other recovery 'tide, something 200?

They're the main ones, melanotan due to being fair skinned is the primary one I've used for the longest time.

Intolerance emerged within such a relatively short space of time since ceasing a good exercise program and essentially becoming sedentary.

i.e. very healthy, to a terrible lifestyle.

It initially emerged at age 34, ages 32 and 33 I was dosing everything without any issue (I stopped proper exercise/lifestyle at 33.5 years old).

Severe intolerance emerged another couple years on again, 36 years old.

And at 37, the mild tinnitus at 36 turned more intense.
 
eidos said:


Take a look at inflammasome (https://en.wikipedia.org/wiki/Inflammasome)

Visceral fat around the pancreas and liver is correlated with their increase.

Click to expand...
Click to expand...

Protective factors (for contrast):

  • Diets rich in omega-3 fatty acids, polyphenols, fiber, vitamin D, and plant foods (e.g., Mediterranean-style) inhibit NLRP3 via reduced ROS, enhanced autophagy/mitophagy, and anti-inflammatory metabolites.
  • Caloric restriction, intermittent fasting, exercise, and weight loss lower NLRP3 activity and improve metabolic health.

Click to expand...
Click to expand...
Sure.

Supports the idea that poor diet/lifestyle promotes chronic inflammation.
 
Have you tried taking pre and probiotics? Fixing your gut microbiome has shown to reduce inflammation and pain from minor injuries as well. I'll leave a link to a recent article breaking down a study comparing a prebiotic vs physical therapy for strength and arthritis pain which is cause by inflammation. This is just one of many studies indicating our guts play a key role in reducing inflammation.



8d28c2faa16ae0e0010f6b70f1db3c68f952a3abfe1315733b1a0c77a39d5d88.webp




A daily fiber supplement reduced knee arthritis pain and improved strength



A prebiotic fiber supplement reduced knee osteoarthritis pain while also improving grip strength and pain sensitivity in a six-week trial. The results hint at a fascinating gut-muscle-pain connection and suggest that a simple daily supplement may be easier to maintain than digital physiotherapy.

www.sciencedaily.com
 
I think your observation about getting back into shape is probably the right direction.

One thing I've learned is that inflammation isn't always something you can "feel" directly. Sometimes it's just subtle things — recovery feels worse, sleep isn't as good, skin changes, energy isn't the same.

Improving fitness and reducing visceral fat seems to improve a lot of those background issues for many people.
 
Metabolic dysfunction (insulin resistance, inflammation, and visceral fat) are the root cause of most health issues people have. When I addressed those issues, my natural Test levels went from 176 to 500. It fixed my skin issues, upset stomach, and other symptoms.

Its the first thing you need to address BEFORE doing peptides other than Reta, Tirz, etc.

I fixed most of it with a strict keto/carnivore diet.
 
aepower2016 said:


Have you tried taking pre and probiotics? Fixing your gut microbiome has shown to reduce inflammation and pain from minor injuries as well. I'll leave a link to a recent article breaking down a study comparing a prebiotic vs physical therapy for strength and arthritis pain which is cause by inflammation. This is just one of many studies indicating our guts play a key role in reducing inflammation.



8d28c2faa16ae0e0010f6b70f1db3c68f952a3abfe1315733b1a0c77a39d5d88.webp




A daily fiber supplement reduced knee arthritis pain and improved strength



A prebiotic fiber supplement reduced knee osteoarthritis pain while also improving grip strength and pain sensitivity in a six-week trial. The results hint at a fascinating gut-muscle-pain connection and suggest that a simple daily supplement may be easier to maintain than digital physiotherapy.

www.sciencedaily.com

Click to expand...
Click to expand...
Started recently.

Chia seeds mixed with greek yoghurt and milk made into a pudding.

Really improved my digestion.

Pre-biotics, I've been going heavy on them for a while now.

But all together probably not long enough yet for complete transformation.

I've excited to see how things progress provided I adhere to them.
 
kenadams said:


Metabolic dysfunction (insulin resistance, inflammation, and visceral fat) are the root cause of most health issues people have. When I addressed those issues, my natural Test levels went from 176 to 500. It fixed my skin issues, upset stomach, and other symptoms.

Its the first thing you need to address BEFORE doing peptides other than Reta, Tirz, etc.

I fixed most of it with a strict keto/carnivore diet.

Click to expand...
Click to expand...
I'm convinced it's why I developed intolerable sides to melanotan.

So I'm going heavy on these diet modifications and seeing do inflammatory issues ease up, upon which time - hopefully - I can start back getting an awesome tan.
 
Back
Top