Injecting endotoxins (lipopolysaccharides from gram-negative bacteria) subcutaneously typically causes localized inflammation and systemic flu-like reactions. [
1,
2,
3]
Local Symptoms at Injection Site
- Redness (Erythema): The skin around the injection site becomes pink or red.
- Swelling (Edema): Fluid builds up, creating a firm or puffy lump.
- Pain and Tenderness: The area hurts when touched or moved.
- Warmth: The skin feels hot to the touch.
- Local Necrosis: In severe or hypersensitive reactions, tissue damage or localized tissue death can occur. [1, 2, 3, 4, 5]
Systemic (Whole Body) Symptoms
- Fever and Chills: A sudden spike in body temperature accompanied by severe shaking chills (rigors).
- Headache and Aches: Generalized muscle aches (myalgia), joint pain (arthralgia), and severe headaches.
- Nausea and Fatigue: Feelings of severe tiredness, malaise, upset stomach, or vomiting.
- Low Blood Pressure: In high doses or severe systemic reactions, blood pressure can drop dangerously low, potentially leading to shock
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