Brenipatide - A GLP1 specifically designed for addiction

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findsource

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Have you heard about the new medication from Lilly Brenipatide. That one is a GLP1 specifically designed for addiction. Have you heard about it or even tried it already? It's in Phase 3 of the clinical trials and looks quite promising
 
LY3537031

looks interesting

Brenipatide (LY-3537031) is an investigational once-monthly subcutaneous dual GLP-1 and GIP receptor agonist developed by Eli Lilly and Company. Unlike metabolic-focused sister peptides, it is specifically optimized for central nervous system and psychiatric indications, currently in Phase 3 trials for alcohol use disorder and bipolar disorder. [1, 2]

Mechanism and Design

    • Dual agonist targeting GLP-1 and GIP receptors simultaneously.
    • Engineered with a backbone modification providing an extended half-life for once-monthly dosing.
    • Optimized for brain and reward-circuitry penetration rather than primary weight loss. [1, 2]

Current Clinical Trials

    • Phase 3: Alcohol use disorder, bipolar disorder, and major depressive disorder.
    • Phase 2: Asthma, schizophrenia, and smoking cessation relapse prevention.
    • Phase 1: Obesity, metabolic disorders, and liver conditions. [1]

If you are looking for specific trial enrollment details or safety data for brenipatide, please let me know which condition you are interested in.

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My first question was going to be "Will this drug curb my addiction to buying peptides?"

Then I realized my brand new 400% higher student loan payments will take care of that for me. 😭

But in all seriousness, if it can do for addictions more than what tirz did for my relationship to alcohol, this sounds amazing. I just hope they make the price point something the non-profits and health orgs can afford to give out to people whose lives have been ruined and upended by addiction.
 
findsource said:


@HouseCat what was your dose tirzepatid that helped for you alcohol cravings

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2.5mg, pretty much as soon as I started. I've gone from 1-2 beers a day/12 a week to less than 6 a month, except for social occasions every other month...I can drink 4/day during a wedding or brunch weekend. I can't tell a difference in tolerance because I now space out social drinks to about 1/hr. so I also no longer have the "3 drinks in--let's make this feeling last FOREVERRRR!" feeling which would inevitably lead to more drinks and hangovers. It was an unexpected side effect, and one that I very much enjoy! I also am choosing lower APV beers (Corona Familiar vs Flying Dog Raging Bitch).
 
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