Depression, and Semax, and SSRIs, oh my!

bk0004 said:


Hello, and thank you to everyone who shared suggestions and experiences.

After doing quite a bit more research, we've decided to try stacking Selank, Semax, and possibly P21. I thought I'd document the journey here in case it ends up helping someone else down the road.

The plan is to introduce one at a time so we can identify any reactions or unwanted side effects before adding the next.

Current plan:

Selank

  • Start at 250 mcg SC
  • Gradually increase to 500 mcg if well tolerated
Semax

  • Start at 250 mcg SC
  • Gradually increase to 500 mcg if well tolerated
P21

  • After completing the second full cycle of Selank and Semax, evaluate mood and anxiety levels.
  • Depending on how she's doing, either adjust the current protocol or introduce P21 (intanasal) at that point.
I'll post updates along the way for anyone interested in following the results. Hopefully our experience can help others who are considering a similar approach.

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2 Week Update:

Responded well to Selank during first week. Reported improved sleep and general feeling of calm. No noticeable effect on depression/anhedonia.

Incorporated Semax in second week. Reported continued effects as experienced with Selank, slight improvement to mood overall. Some GI distress, believe unrelated but will continue to monitor.

Will continue on combo for 2 additional weeks, then cycle off. Next cycle will increase dose incrementally.

My thoughts: I have been pleasantly surprised by the effects so far, however, I am reserving judgment because there is a good likelihood there is some placebo effect going on. I hope that with time the positive effects continue. Will continue to update periodically.
 
Clavicular's Hammer said:


Not currently depressed but wondering if you’ve tried a glp1?

Reta really gives me a steady state of satisfaction. Don’t feel the need for a drink or really anything else

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Unfortunately with her low weight and eating disorder history, I would hesitate to do a GLP1.

I agree though as a GLP1 user - tirzepatide did wonders for my overall wellness (mental and otherwise)!
 
bk0004 said:


Hello, and thank you to everyone who shared suggestions and experiences.

After doing quite a bit more research, we've decided to try stacking Selank, Semax, and possibly P21. I thought I'd document the journey here in case it ends up helping someone else down the road.

The plan is to introduce one at a time so we can identify any reactions or unwanted side effects before adding the next.

Current plan:

Selank

  • Start at 250 mcg SC
  • Gradually increase to 500 mcg if well tolerated
Semax

  • Start at 250 mcg SC
  • Gradually increase to 500 mcg if well tolerated
P21

  • After completing the second full cycle of Selank and Semax, evaluate mood and anxiety levels.
  • Depending on how she's doing, either adjust the current protocol or introduce P21 (intanasal) at that point.
I'll post updates along the way for anyone interested in following the results. Hopefully our experience can help others who are considering a similar approach.

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Adamax and Adalank should be the target, imo.

I haven’t tried them myself, but the full fat versions, not the dogshit most vendors peddle and pretend to be authentic, are much longer acting and are more effective than Semax/Selank.
 
Shittersfull said:


My wife has had anxiety and depression for a long time. Semax and selank didn't do much for her, but we will try again. What did help was oxytocin. Made her more in tune with herself and what is important to her.

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Really? Can you elaborate on this a little more? I'm kind of in the same boat and trying to find some answers and have been looking into oxytocin.
 
That said, unapproved and unstudied nootropics scare the shit out of me. Like, shooting crazy shit straight past the blood brain barrier is not trivial… and I think we forget about the risks in this space.

And I don’t think many people will be happy to read this.
 
tryingzen said:


Really? Can you elaborate on this a little more? I'm kind of in the same boat and trying to find some answers and have been looking into oxytocin.

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Well it's hard for me to describe, as it doesn't work for me. My wife takes 100mcg sq. Within minutes she feals love, relaxation and comfort. She no longer feels like she needs to be in control of things that are out of her control. That's exactly how she describes Sq. It's harder to find, but no to expensive when you do run into it.
 
I know you mentioned herbs and ssri but I’m curious if she tried mushrooms? They’ve been shown to help. But on peptides, I’ve struggled with anxiety since giving birth 5 years ago from birth ptsd, and selank has helped a little bit. I get amped up with Semax so I don’t use that. I’ve just started looking into Adamax though and it may be a better option. I also know you can sub q the semax and selank or some people turn it into a nasal spray, not sure if there’s a difference in effect but I do sub q for it. I was really hoping selank would give me more of a benefit…idk no ssri or snri has helped and tbh I’m feeling like I’m just broken and doomed to suffer forever at this point 😫
 
Bird_of_Hermes said:


I haven’t tried them myself, but the full fat versions, not the dogshit most vendors peddle and pretend to be authentic, are much longer acting and are more effective than Semax/Selank.

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Lol...you do realize that your above statement carries a bit of unfounded humor, amirite?...😎
 
CrimsonTaco47 said:


I know you mentioned herbs and ssri but I’m curious if she tried mushrooms? They’ve been shown to help. But on peptides, I’ve struggled with anxiety since giving birth 5 years ago from birth ptsd, and selank has helped a little bit. I get amped up with Semax so I don’t use that. I’ve just started looking into Adamax though and it may be a better option. I also know you can sub q the semax and selank or some people turn it into a nasal spray, not sure if there’s a difference in effect but I do sub q for it. I was really hoping selank would give me more of a benefit…idk no ssri or snri has helped and tbh I’m feeling like I’m just broken and doomed to suffer forever at this point 😫

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If Semax amps you up, Adamax will do that x10.

Have you looked into PE-22-28? Many RSs have said it helps lighten mood and reduce depression, but there are no human studies.

Or Oxytocin? If you like Selank, also look into NA Selank Amidate. It a bit stronger and lasts longer.
 
CrimsonTaco47 said:


I know you mentioned herbs and ssri but I’m curious if she tried mushrooms? They’ve been shown to help. But on peptides, I’ve struggled with anxiety since giving birth 5 years ago from birth ptsd, and selank has helped a little bit. I get amped up with Semax so I don’t use that. I’ve just started looking into Adamax though and it may be a better option. I also know you can sub q the semax and selank or some people turn it into a nasal spray, not sure if there’s a difference in effect but I do sub q for it. I was really hoping selank would give me more of a benefit…idk no ssri or snri has helped and tbh I’m feeling like I’m just broken and doomed to suffer forever at this point 😫

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Hadn't considered it, but her on shrooms might be fun. 😂
 
bk0004 said:


Hadn't considered it, but her on shrooms might be fun. 😂

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I should have mentioned it’s not just taking shrooms lmao it’s microdosing but there’s ways to get it online and in capsules and other ways. I got it in a chocolate powder so I’d add it to my coffee. It helped a lot for a bit
 
CrimsonTaco47 said:


I should have mentioned it’s not just taking shrooms lmao it’s microdosing but there’s ways to get it online and in capsules and other ways. I got it in a chocolate powder so I’d add it to my coffee. It helped a lot for a bit

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Just a jest. 😉 I know we're not talking tripping loads of magic mushrooms.

Are you referring to lion's mane and reishi? I saw some drink mixes and gummies that had those in them and a few people were saying positive things.
 
Bird_of_Hermes said:


Adamax and Adalank should be the target, imo.

I haven’t tried them myself, but the full fat versions, not the dogshit most vendors peddle and pretend to be authentic, are much longer acting and are more effective than Semax/Selank.

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Are there any vendors carrying adalank? I have never seen that pep at any vendors I use.
 
Goonwise said:


Are there any vendors carrying adalank? I have never seen that pep at any vendors I use.

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According to my friendly AI, adalank is N-Acetyl Selank Amidate. And there are several vendors on here that carry it. If you mean the equivalent to Adamax where it has an Adamantane, no, I haven't seen it being sold
 
4ResearchPurposes said:


According to my friendly AI, adalank is N-Acetyl Selank Amidate. And there are several vendors on here that carry it. If you mean the equivalent to Adamax where it has an Adamantane, no, I haven't seen it being sold

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That's what true Adalank is supposed to be tho, the corollary to Adamax. NA Selank with the adamantane cage on the end or NA+Selank+adamantane. It should be ~930 Da. I haven't seen the real thing accept with some single vial and spray sellers, so I won't purchase it.
 
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