Looking for more science on NAD+ injections, precursors may be more effective

Clavicular's Hammer

Clavicular's Hammer

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Hi,

Watched a video on NAD+ injections and then did a quick copilot ai search to confirm and wanted to start a conversation.

So it appears that the NAD+ molecule is too large and charged to cross the cell barrier. Our bodies break it down to precursers then bring those into the cell.

Actual precursers in supplement form convert at a rate of 60-70% to NAD+ in our bodies.

So from what I’ve gathered we would all save ourselves one peptide from the stack by just taking precursers.

What’s everyone’s understanding here?
 
Clavicular's Hammer said:


Hi,

Watched a video on NAD+ injections and then did a quick copilot ai search to confirm and wanted to start a conversation.

So it appears that the NAD+ molecule is too large and charged to cross the cell barrier. Our bodies break it down to precursers then bring those into the cell.

Actual precursers in supplement form convert at a rate of 60-70% to NAD+ in our bodies.

So from what I’ve gathered we would all save ourselves one peptide from the stack by just taking precursers.

What’s everyone’s understanding here?

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nad+ work very well with oral so one less thing to pin
 
Mr. Blonde said:


What are the precursors? Also are they injected or oral?

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Oral and I think any of these helps the body make its own fairly effectively:

NMN (Nicotinamide mononucleotide)

NR (nicotinamide riboside)

Niacin

Tryptophan

Nicotinamide
 
Clavicular's Hammer said:


Hi,

Watched a video on NAD+ injections and then did a quick copilot ai search to confirm and wanted to start a conversation.

So it appears that the NAD+ molecule is too large and charged to cross the cell barrier. Our bodies break it down to precursers then bring those into the cell.

Actual precursers in supplement form convert at a rate of 60-70% to NAD+ in our bodies.

So from what I’ve gathered we would all save ourselves one peptide from the stack by just taking precursers.

What’s everyone’s understanding here?

Click to expand...
Click to expand...
We don't really know, at this point, how NAD+ injections interact with cells based upon the reading I've done. There was an interesting study I read by authors investigating this that suggest there may, there may, in fact be a transporter on the cell membrane that allows the cell to directly take up NAD+. This would not surprise me given how sparse our knowledge of the science is.
 
tendency said:


We don't really know, at this point, how NAD+ injections interact with cells based upon the reading I've done. There was an interesting study I read by authors investigating this that suggest there may, there may, in fact be a transporter on the cell membrane that allows the cell to directly take up NAD+. This would not surprise me given how sparse our knowledge of the science is.

Click to expand...
Click to expand...

That could be true

I think for me, from what we know for sure, in more inclined to skip NAD+ as a peptide for now.

Seems like most people can synthesize their own efficiently given the right inputs
 
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