Mental health and reta in particular

kazza94x said:


Do you find anything "does it" for you at all or is it completely blunted ? If you also take any antis, they could be contributing to this.

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Cats. Working on art projects to some extent or another. I won't go into the full litany of fun I have to live with, but it certainly makes life... interesting or complicated, maybe both? As for antis.. no. My physician started me on some, but my therapist suggested that I stop taking them when I began feeling more 'blunted' than I am now.
 
kazza94x said:


Hi fellow peps,

I have noticed an increase in feeling flat, tired, exhausted, extreeme fatigue, very dry skin and just feeling a bit empty.

I am seeing a therapist and doctor etc but this has started amping up since reta, i was on sema before without any issues.

I wonder if anyone has any similar experiences with this?

When did it start?

How bad is it?

How do you cope ?

Only if comfortable with answering. No pressure.

Click to expand...
Sorry, i have a lot to say about this so it will be really long.

I struggle with anhedonia in general and have for years. But it has gotten worse over the last year and esp since starting tirz at the beginning of this year.

After a lifetime of trying to deal with this here are my suggestions:

1-get your hormones tested. If you are female and are still menstruating, ask for a full hormone panel. Peri-menopause can start in your 30s and even earlier if you have any hormone disruption, which obesity does. If you are female and no longer menstruating, ask about hormones replacement including testosterone supplementation. If you are male, obesity also disrupts hormones for you, and testosterone replacement can be life-changing if needed.

2-The number one lifestyle change you can make to improve anhedonia is savoring. Actively look for things that feel good, might feel good, or should feel good. Then deliberately engage in those behaviors and really, consciously, savor/wallow/engage in the behavior. Tell yourself "this is fun, I'm having a good time, I'm enjoying this". I know it sounds dumb, but you can convince your brain to increase the release of positive chemicals by changing the thoughts you have about the situation.

3. Look at what causes release of the feel good chemicals and do each of them every day: dopamine is the reward chemical, so engage in reward seeking behavior-this means setting goals and meeting them, giving yourself rewards for "good behavior", and listening to music (the anticipation networks of our brains find music HIGHLY rewarding). Oxytocin is the bonding chemical-hug someone, cuddle, have sex, kiss for a long time, pet your dog. Serotonin is the contentment chemical-it is released when you are ok. You are good. Nothing bad is happening. So look for ways to find joy in the small things, be present and let your brain rest (PUT DOWN THE PHONE), and spend some time just noticing that you are good right now. Endorphins are the energy and pain relief chemicals- workout really hard, do things that excite you, have adventures. Finally, GABA is the rest and relax chemical. Meditate, breathe, progressive muscle relaxation, yoga.

4. NOTE: A LOT of people feel anhedonia when the anxiety goes away. If you are regularly anxious, your brain is primed to look for threat and the experience of less anxiety feels like flatness, like something is wrong. Learning to be ok with the lack of threat is the only way to make the flatness feel better.

5. Supplements that I have found helpful- 5htp (this has been a literal lifesaver for me in the past when the anhedonia was accompanied by pretty severe depression). Tyrosine (not the best for me but takes the edge off and increases mood slightly). DLPhenylalanine-this makes the biggest impact on my overall mood and ability to engage in positive behaviors.
 
kazza94x said:


That sounds terrible, I spend most of my time at home also and away from people. I think it may take some time to find ourselves before we had a toxic relationship with food. What do you think?

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I'm not even sure there was a time that I didn't have a toxic relationship with food.
 
As a former addict with depressive dominant bipolar disorder, my mental health prior to starting reta was actually so bad that reta-induced anhedonia has been a major improvement in my life. It's so nice to just feel "flat" rather than feeling constant suffering.

I've been on reta for around four months now, and I never went beyond ~5mg per week. I understand that the anhedonia can be much more severe at higher doses.

But there's also a LOT going on under the hood for me to manage this. I couldn't imagine taking reta alone without having my supplement stack dialed in.

I take benofitamine, calcium pantothenate, riboflavin, P5P, riboflavin, a sublingual B12 complex, and methylfolate.

Those are just the individual components of a B-complex, the tip of the iceberg.

I also take a host of trace minerals as needed (boron and copper are amazing if you've never got them dialed in before), zinc, incredible amounts of magnesium. Not to mention potassium and sodium in water as needed. D3/K2 as well.

I take taurine, glycine, TMG, phosphatidylcholine, fish oil, recently been messing with lithium orotate which has been amazing for obessive and axious feelings but has complex interactions with the methylation system and folate/B12 uptake.

And there are so many other supplements that I can't afford at the moment but need to introduce... CoQ10 and L-Carnitine are big ones that I'm excited for.

And all of this on top of just balancing macros and diet. Sometimes the macros are right but I feel like shit because sleep or exercise are out of whack or because I haven't eaten an honest vegetable in a month.

it's a lot to balance. Quite frequently I'll run out of some crucial vitamin and can't afford to replace it in time, or I take too much of something and it all comes crashing down and I feel like shit for a week and have to back off and re-assess.

Some people are of the opinion that this is optional and that you can get everything you need from diet. I think that's a bad joke. I couldn't imagine taking reta if I didn't have this foundational knowledge of supplemental nutrition.

Bare minimum, get a B complex, get a trace mineral complex, take magnesium glycinate separately, and get an electrolyte blend with an efficacious dose of potassium to get on top of your electrolytes. If you won't do that much, only God can help you.
 
tryingzen said:


1-get your hormones tested. If you are female and are still menstruating, ask for a full hormone panel. Peri-menopause can start in your 30s and even earlier if you have any hormone disruption, which obesity does. If you are female and no longer menstruating, ask about hormones replacement including testosterone supplementation. If you are male, obesity also disrupts hormones for you, and testosterone replacement can be life-changing if needed.

Click to expand...
To add to this from a male perspective, not only does obesity wreck your hormones and make you more estrogen dominant, but being in a calorie deficit (particularly if your diet is low in good fats) also wrecks your hormones. If you're losing 2+lbs per week your testosterone is likely at hypogonadal levels. Once you hit a healthy weight, your test will likely bounce back to better than it was pre-GLP. In the meantime (see my other post), things like boron, zinc, selenium, copper, healthy fats, and L-Carnitine can support your test if you don't want to take the full plunge on educating yourself and getting blood tests done.

Also, for menopausal women, and men for that matter, you can get your own blood tests and do HRT yourself. /r/trt_females is a great place to look around and see what other women are doing. Beware of the pellet.

tryingzen said:


3. Finally, GABA is the rest and relax chemical. Meditate, breathe, progressive muscle relaxation, yoga.

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All good info, and glad you brought up GABA. I started pregnenolone supplementation (nutricost 10mg) and it was great for my anxiety. Combined with lithium orotate and i almost feel normal some days.

Pregnenolone for men is sort of like progesterone supplementation for women, it's the hormonal precursor to gabaergic neurosteroids.

tryingzen said:


4. NOTE: A LOT of people feel anhedonia when the anxiety goes away.

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This! And doubly so if you're unemployed and have no hobbies.

tryingzen said:


5. Supplements that I have found helpful- 5htp (this has been a literal lifesaver for me in the past when the anhedonia was accompanied by pretty severe depression). Tyrosine (not the best for me but takes the edge off and increases mood slightly). DLPhenylalanine-this makes the biggest impact on my overall mood and ability to engage in positive behaviors.

Click to expand...
I have to caution others against using 5HTP. Many, many people have problems with it and it's not a safe way to boost serotonin. L-Tryptophan is a much safer option.

sheilarae74 said:


I'm not even sure there was a time that I didn't have a toxic relationship with food.

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Yeah you're not shitting me. Food was my starter drug. I've been killing large pizzas since I was a 200lb 12 year old.
 
birdwhacker said:


Yeah you're not shitting me. Food was my starter drug. I've been killing large pizzas since I was a 200lb 12 year old.

Click to expand...
This and other posts are like reading the story of my life haha.

My first addiction was food, the second was drugs, after a while i had lost all the weight and looked great for the first time ever but i really leaned into the drugs for years becoming in the end non functional really, then after a very serious mental health related breakdown i finally put the years of drug addiction behind me with the help of family, doctors and medication, but i went back IMMEDIATELY to my original poison, my first love and comfort since boyhood, food! And I ballooned..

But now i'm down 9 kilos in 4.5 weeks thanks to Reta💪 the adhedonia has come to be a bit of relief as i have bad ADHD and Reta has i 100% believe brought some peace to my mind, concentration is definitely up. Feeling positive feels new. 🫡
 
tryingzen said:


Sorry, i have a lot to say about this so it will be really long.

I struggle with anhedonia in general and have for years. But it has gotten worse over the last year and esp since starting tirz at the beginning of this year.

After a lifetime of trying to deal with this here are my suggestions:

1-get your hormones tested. If you are female and are still menstruating, ask for a full hormone panel. Peri-menopause can start in your 30s and even earlier if you have any hormone disruption, which obesity does. If you are female and no longer menstruating, ask about hormones replacement including testosterone supplementation. If you are male, obesity also disrupts hormones for you, and testosterone replacement can be life-changing if needed.

2-The number one lifestyle change you can make to improve anhedonia is savoring. Actively look for things that feel good, might feel good, or should feel good. Then deliberately engage in those behaviors and really, consciously, savor/wallow/engage in the behavior. Tell yourself "this is fun, I'm having a good time, I'm enjoying this". I know it sounds dumb, but you can convince your brain to increase the release of positive chemicals by changing the thoughts you have about the situation.

3. Look at what causes release of the feel good chemicals and do each of them every day: dopamine is the reward chemical, so engage in reward seeking behavior-this means setting goals and meeting them, giving yourself rewards for "good behavior", and listening to music (the anticipation networks of our brains find music HIGHLY rewarding). Oxytocin is the bonding chemical-hug someone, cuddle, have sex, kiss for a long time, pet your dog. Serotonin is the contentment chemical-it is released when you are ok. You are good. Nothing bad is happening. So look for ways to find joy in the small things, be present and let your brain rest (PUT DOWN THE PHONE), and spend some time just noticing that you are good right now. Endorphins are the energy and pain relief chemicals- workout really hard, do things that excite you, have adventures. Finally, GABA is the rest and relax chemical. Meditate, breathe, progressive muscle relaxation, yoga.

4. NOTE: A LOT of people feel anhedonia when the anxiety goes away. If you are regularly anxious, your brain is primed to look for threat and the experience of less anxiety feels like flatness, like something is wrong. Learning to be ok with the lack of threat is the only way to make the flatness feel better.

5. Supplements that I have found helpful- 5htp (this has been a literal lifesaver for me in the past when the anhedonia was accompanied by pretty severe depression). Tyrosine (not the best for me but takes the edge off and increases mood slightly). DLPhenylalanine-this makes the biggest impact on my overall mood and ability to engage in positive behaviors.

Click to expand...
would a regular doc do hormone testing or do I need gyno. I need to make a well check appt. post menopausal and I feel like I could use a boost. Very helpful post. If a woman needs testosterone, is it the same kind people are getting on forums or is it something different for women. That sounds dumb, and the answer is probably same, but I dont wanna get chest hair!! hahaha
 
Thighknee said:


This and other posts are like reading the story of my life haha.

My first addiction was food, the second was drugs, after a while i had lost all the weight and looked great for the first time ever but i really leaned into the drugs for years becoming in the end non functional really, then after a very serious mental health related breakdown i finally put the years of drug addiction behind me with the help of family, doctors and medication, but i went back IMMEDIATELY to my original poison, my first love and comfort since boyhood, food! And I ballooned..

But now i'm down 9 kilos in 4.5 weeks thanks to Reta💪 the adhedonia has come to be a bit of relief as i have bad ADHD and Reta has i 100% believe brought some peace to my mind, concentration is definitely up. Feeling positive feels new. 🫡

Click to expand...
id be humongous if I lived in Ireland. Tayto sambos with Kerrygold on Brennans would be my vice.
 
kazza94x said:


Hi fellow peps,

I have noticed an increase in feeling flat, tired, exhausted, extreeme fatigue, very dry skin and just feeling a bit empty.

I am seeing a therapist and doctor etc but this has started amping up since reta, i was on sema before without any issues.

I wonder if anyone has any similar experiences with this?

When did it start?

How bad is it?

How do you cope ?

Only if comfortable with answering. No pressure.

Click to expand...
Hi!

I'm pretty new but this has happened to me due to really super hot weather and mounjaro. People love summer but I've never really liked summer. It is not new

I have decreased monjuaro from 2,5 to 1,25 and add reta 0,50 because I couldn't train, no joking here.

Do you have something that you absolutely love? In my case is music, dancing and my dog. Do that more even if in the first place you don't feel like starting. Give it a try, please.

I'm not an expert at all. I have dealt with severe depression and I know how you feel but please, don't give up. No just yet.

Eat your protein, take BCAA'S (I sense glucagon has no mercy at all) and even you don't want to eat fruit o potato (carbs) eat them.

What helps me too is going for a walk and be in the present moment. Sun resets our circadian rhythms.

I know it sounds super basic but I want to encourage you.

Sending you lot of good energy
 
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