Might be a stupid question

Labcat said:


The only thing I think about is that the longer we are at an unheathy weight, the longer that unhealthy weight’s related issues like inflammation are affecting our health in possibly an irreversible way.

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My BP has dropped dramatically in the past 5 during over my 50-pound loss. Even without the weight loss, I'm glad that I'm getting to a healthy BP faster.
 
I have stuck with only losing 1-2 lbs a week for the past year and a half. At 52, I am convinced this method has kept my skin from sagging worse than it has been.
 
I think that the window of opportunity is a very real thing. You do get used to the drugs and they do become less efficacious. Max out your weight loss while appetite control is high is as calid a strategy as any. Theres also evidence of the setpoint theory that your body will loose weight until it gets to its new “equilibrium”. In either case, the only thing that the take it slow approach can probably give you is more fat mass loss vs lean body mass if you train and eat properly.

Also regarding skin laxity i dont think there is any correlation. If your skin has stretched out beyond your elasticle capacity you will have loose skin. Period. Its genetic to some extent and depends on your fat gain %.
 
I am working out almost every night, I don't want to be skinny fat. I just started klow to prevent the skin laxity (hopefully). Maybe I'll look like I'm 20 again (and maybe pigs will fly).
 
Devilseye said:


I think that the window of opportunity is a very real thing. You do get used to the drugs and they do become less efficacious. Max out your weight loss while appetite control is high is as calid a strategy as any. Theres also evidence of the setpoint theory that your body will loose weight until it gets to its new “equilibrium”. In either case, the only thing that the take it slow approach can probably give you is more fat mass loss vs lean body mass if you train and eat properly.

Also regarding skin laxity i dont think there is any correlation. If your skin has stretched out beyond your elasticle capacity you will have loose skin. Period. Its genetic to some extent and depends on your fat gain %.

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I would agree with all of this, the only thing I would add is that we don't know the role of using multiple glp-1s or other treatments after the window of opportunity to encourage more weight loss.

What is clear, at least for tirzepatide, is that weight loss plateaus at about 12-15 months and patients stay at the lower weight as long as treatment is continued and that there is no significant additional weight loss after the 12-15 months.

What we don't know is what happens after the window if the patient switches to reta or adds phentermine, phentermine/topiramate, or naltrexone/bupropion to tirzepatide in combination. Will that carry the patient to "goal". I'm not sure that there is any evidence or current clincial guidlines for what to do when folks don't reach their weightloss goal on their first glp-1.
 
Devilseye said:


I think that the window of opportunity is a very real thing. You do get used to the drugs and they do become less efficacious. Max out your weight loss while appetite control is high is as calid a strategy as any. Theres also evidence of the setpoint theory that your body will loose weight until it gets to its new “equilibrium”. In either case, the only thing that the take it slow approach can probably give you is more fat mass loss vs lean body mass if you train and eat properly.

Also regarding skin laxity i dont think there is any correlation. If your skin has stretched out beyond your elasticle capacity you will have loose skin. Period. Its genetic to some extent and depends on your fat gain %.

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And age. Laxity also depends on age.
 
HereKittyKitty said:


And age. Laxity also depends on age.

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I think age is a huge factor. My skin was never stretched out beyond capacity since I don't have stretch marks and didn't have lose skin after my pregnancies, even though my total weight at the end of those was considerably more than my total weight before starting GLP-1, and I did lose weight after my pregnancies. But that was also 11 years ago, and now my weight loss wasn't superfast, but my skin is loose and feels thin.
 
Grogu said:


My fear for people who have a lot of weight to lose, is that they somehow perceive that low and slow is "better" and "less cheating" and forego the full benefits of treatment and then don't reach the weight loss goals they could have if they had taken a more aggressive (if they can tolerate it) dose escalation regime.

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This! On a lot of the subs in Reddit and FB and such there is a near cult of Low and Slow, and while that works for some, as you noted the studies showed that if you have a lot to lose, you'll see best results on the higher doses, there's no advantage to hanging low. But my God, there are groups where I could point that out and get my head take off.
 
spanky2026 said:


This! On a lot of the subs in Reddit and FB and such there is a near cult of Low and Slow, and while that works for some, as you noted the studies showed that if you have a lot to lose, you'll see best results on the higher doses, there's no advantage to hanging low. But my God, there are groups where I could point that out and get my head take off.

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And for those of us who partake in TV, we're bombarded daily by Rebel Wilson espousing the benefits and virtues of microdosing. "Micro changes, big results". 😂 She's not fat Amy anymore, she's the microdosing spokeswoman.

I have to be honest, when I first looked into Zepbound and read online, I too thought that low and slow was best. Then I read the clincial trials and a bunch of scientific materials, and yeah no. That's not right for most people.
 
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