Mots-C a few hrs before endurance exercise

gimmeshelter

gimmeshelter

New member
Joined
Aug 19, 2026
Messages
42
Reaction score
0
Location
Imported archive
I bought some Mots and my hope was to using it a couple hrs before either a gym session or a cardio session ( I road bike ride 30-60 miles at a time and it’s intense cardio) I was not planning taking, for example, 15mg across 3 days in a given week. ONLY take before I jump on my road bike.

I have seen some threads who say that would give me a boost in performance, some say the opposite. Since mots is cheap, I figured I’d grab a kit and try. The boost I want is not to beat other but to allow me to have a hard session and get my gains there.

Have other RS used mots just before endurance work with success? I am thinking of starting low, 5mg and go up from there. I have ready u need as much as 15mg for performance gains w the range being 10-15mg.
 
Following.

I have a kit of MOTS-C ready to go but I haven't started it yet because I'm still experimenting with KLOW and I don't want to make it complicated.

I don't even really do cardio, I jog sometimes? I just want to squat.
 
gimmeshelter said:


I bought some Mots and my hope was to using it a couple hrs before either a gym session or a cardio session ( I road bike ride 30-60 miles at a time and it’s intense cardio) I was not planning taking, for example, 15mg across 3 days in a given week. ONLY take before I jump on my road bike.

I have seen some threads who say that would give me a boost in performance, some say the opposite. Since mots is cheap, I figured I’d grab a kit and try. The boost I want is not to beat other but to allow me to have a hard session and get my gains there.

Have other RS used mots just before endurance work with success? I am thinking of starting low, 5mg and go up from there. I have ready u need as much as 15mg for performance gains w the range being 10-15mg.

Click to expand...
Click to expand...

Regarding dosing, I would never go above 10 mg for MOTS-c, personally. Risk of a systemic reaction would only seem to be higher. For the same reason, I would never do IM, only subq.

Gemini:

Higher doses don't necessarily provide linear benefits, but they exponentially increase the likelihood of systemic side effects like flushing, rapid heart rate, or widespread lethargy. Keeping it at or below 10 mg manages that risk profile effectively.

Click to expand...
Click to expand...
By the way, I would ask AI for tips to prevent ISRs on MOTS-c. One option may be KPV mixed in the same syringe, along with taking breaks away from it. The KPV can be reconned with saline BAC.
 
mybodyisasewer said:


Following.

I have a kit of MOTS-C ready to go but I haven't started it yet because I'm still experimenting with KLOW and I don't want to make it complicated.

I don't even really do cardio, I jog sometimes? I just want to squat.

Click to expand...
Click to expand...
Ya mots-t should give u a boost before workouts but do does 200mg caffeine . For endurance mots is said to make a measurable difference . For example I could measure avg watts on a hard ride , if 3-4% above what I normally do think that would be a legit difference not placebo. Who knows w r all RS’s!

KLOW man in repair, skin & inflammation, correct ? Bought some for buddy off GB was chhheap

Calm Logic said:


By the way, I would ask AI for tips to prevent ISRs on MOTS-c. One option may be KPV mixed in the same syringe, along with taking breaks away from it. The KPV can be reconned with saline BAC.

Click to expand...
Click to expand...
i have seen some posts on that , I plan to start low and see if I get any reactions , right now if I was to get a big reaction I’d prolly just give it up as I don’t want to introduce another pepper, trying to keep it simple
 
jbrown15 said:


I run MOTS-C and pin at 5mg three times a week. I love it, seen great results with it while running a mitochondria stack for the last 9 weeks.

Click to expand...
Click to expand...
So 9 week cycle 15mg a week? U oin same time or an hr or so before ur run?
 
Before I go for my morning run I take 2mg of Motsc via a nasal spray. I feel I have slightly more endurance than without. However I am I a currently working on improving my insulin resistance. I wouldn’t expect the same effects in someone who has better insulin signaling.
 
I go 8mg EOD MOTS-c and alternate with NAD+ 100mg. Both pre workout fasted in the AM. SS31 10mg daily after lunch. My mitochondria is now optimal. Been running for 6 months.
 
chewonmysac said:


I go 8mg EOD MOTS-c and alternate with NAD+ 100mg. Both pre workout fasted in the AM. SS31 10mg daily after lunch. My mitochondria is now optimal. Been running for 6 months.

Click to expand...
Click to expand...
Have you calculated your

HOMA-IR (Homeostatic Model Assessment for Insulin Resistance)

To measure your mitochondrial function?
 
Turbo-Farmer said:


Have you calculated your

HOMA-IR (Homeostatic Model Assessment for Insulin Resistance)

To measure your mitochondrial function?

Click to expand...
Click to expand...
I have not. Will confirm Insulin and glucose to blood work this week. Will report back. Just going by how well I feel with everything dialed in. Diet, exercise and sleep. Just started HGH 10 days ago so expecting to see some action from that. Hopefully the Tirz is offsetting some of the insulin resistance.
 
jbrown15 said:


It’s a 12 week cycle, tomorrow is the start of week 10 and yes I dose15mg a week split over three doses. I dose in the morning.

Click to expand...
Click to expand...
Did you start your mots c journey with 15mg a week or work your way up to it ?
 
On 5 mg pre-cardio, my energy feels very stable and I can keep going for a long time without any noticeable drop. The downside is that later in the day, even hours after the cardio, I feel completely drained, almost like I emptied the tank and took a big hit to my overall energy.

I know some people use 1–2 mg daily, and I’m wondering whether a lower dose could provide more consistent energy for cardio without causing that delayed crash. I even used SS-31 both before and during this period, but it didn’t seem to prevent the exhaustion afterward.
 
gimmeshelter said:


I bought some Mots and my hope was to using it a couple hrs before either a gym session or a cardio session ( I road bike ride 30-60 miles at a time and it’s intense cardio) I was not planning taking, for example, 15mg across 3 days in a given week. ONLY take before I jump on my road bike.

I have seen some threads who say that would give me a boost in performance, some say the opposite. Since mots is cheap, I figured I’d grab a kit and try. The boost I want is not to beat other but to allow me to have a hard session and get my gains there.

Have other RS used mots just before endurance work with success? I am thinking of starting low, 5mg and go up from there. I have ready u need as much as 15mg for performance gains w the range being 10-15mg.

Click to expand...
Click to expand...
I run 3.33mg Mots-C every other day in the morning and have noticed to have much more endurance in the gym and doing cardio after weight training. I’ll be in the gym for like 2hrs a day between weight training, cardio, and sauna afterwards, and I feel great during the whole thing.

Could it be placebo of myself getting healthier and more in shape, maybe… but I feel like it has definitely helped since I started it.
 
Have you experience how endurance effects change after you stop taking MOTS? Are the effects maintained or do you basically use it forever if you want the boost? I'm talking about aerobic base but also hard Zone4/5 intensities.
 
Turbo-Farmer said:


Awesome, your mitochondria might not need or benefit as much from supplemental MOTS-c.

Click to expand...
Click to expand...
I am going to take a 90-day break from MOTS-c. Got really tired after lunch this week and was trying to figure out which one was causing it, and by process of elimination, I determined it was the MOTS-c. This can happen when my body gets enough and starts to raise homocysteine. Will still run NAD+ EOD and SS-31 daily. Tough being a Rat out here.
 
Back
Top