Switching from Reta to other (generic) GLP-1R agonist

Ontbijtkoek

Ontbijtkoek

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I've tried retatrutide up to 12 mg, and it didn't seem to do anything for me besides cause severe bloating. It didn't give me any appetite suppression, nor did it reduce my food noise. It did seem to work slightly in the beginning at the lower doses, but that faded away rather quickly. I'm not looking for extreme weight loss, but rather a tool that will allow me to adhere to a good diet and moderate calorie deficit so I can improve my physical and mental health. I could probably benefit from losing around 5 - 8 kg (11 - 18 lbs), but at the moment I'm just looking for something that will suppress my appetite and possibly food noise so I can spend my (mental) energy on things that are actually productive.

I recently bought a kit of tirzepatide, semaglutide, and cagrilintide. I'm currently 2 weeks off retatrutide and will soon be trying out one of these three compounds and potentially stacking the amylin analogue with a GLP-1 if necessary. I obviously want to take things slow instead of throwing the kitchen sink at it, so I'm wondering which compound I should consider trying first.

Also, if any of you have had a similar experience with Reta and switched to another compound, I'd love to hear your story.
 
Ontbijtkoek said:


I've tried retatrutide up to 12 mg, and it didn't seem to do anything for me besides cause severe bloating. It didn't give me any appetite suppression, nor did it reduce my food noise. It did seem to work slightly in the beginning at the lower doses, but that faded away rather quickly. I'm not looking for extreme weight loss, but rather a tool that will allow me to adhere to a good diet and moderate calorie deficit so I can improve my physical and mental health. I could probably benefit from losing around 5 - 8 kg (11 - 18 lbs), but at the moment I'm just looking for something that will suppress my appetite and possibly food noise so I can spend my (mental) energy on things that are actually productive.

I recently bought a kit of tirzepatide, semaglutide, and cagrilintide. I'm currently 2 weeks off retatrutide and will soon be trying out one of these three compounds and potentially stacking the amylin analogue with a GLP-1 if necessary. I obviously want to take things slow instead of throwing the kitchen sink at it, so I'm wondering which compound I should consider trying first.

Also, if any of you have had a similar experience with Reta and switched to another compound, I'd love to hear your story.

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Ive seen a lot of recent posts where folks are unimpressed with reta, myself included. I get a lil jelly reading about people on 2mg with incredible results. Theres a big tirz cult here, I think youll like it.
 
Airborne Daddy said:


Ive seen a lot of recent posts where folks are unimpressed with reta, myself included. I get a lil jelly reading about people on 2mg with incredible results. Theres a big tirz cult here, I think youll like it.

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I've indeed noticed that a lot of people tend to recommend tirzepatide over the other GLPs. Your comment is just additional confirmation that this is probably the superior choice for me, thanks.
 
Airborne Daddy said:


Ive seen a lot of recent posts where folks are unimpressed with reta, myself included. I get a lil jelly reading about people on 2mg with incredible results. Theres a big tirz cult here, I think youll like it.

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Tirz Cult member here, yeah as I was reading your description of what you needed I thought definitely Tirz, fits what you need. Sema has more severe side effects for many people.
 
I'm one of those that responded - and still do - really well to Reta. Never had to go above 3.5mg/week. Wife lost 35lb never going above 2.5mg/week. Nothing shreds fat like Reta and for those for whom it works it's the best .. at least that's what I've seen. Good luck!
 
spanky2026 said:


Tirz Cult member here, yeah as I was reading your description of what you needed I thought definitely Tirz, fits what you need. Sema has more severe side effects for many people.

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Have you tried any of the other glp1s or did you go straight with tirzepatide?
 
tendency said:


I'm one of those that responded - and still do - really well to Reta. Never had to go above 3.5mg/week. Wife lost 35lb never going above 2.5mg/week. Nothing shreds fat like Reta and for those for whom it works it's the best .. at least that's what I've seen. Good luck!

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Seems like the response varies a lot depending on the individual, maybe due to some genetic polymorphisms.
 
spanky2026 said:


Tirz Cult member here

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Hahahhahahaha I never thought of myself as a cult member, but apparently, I am.

Tirz cult member #2 here.....I love Tirz, I do have some Reta and cag in the barrel if I want or needs it tho
 
Second thread in an hour that Reta is getting fried. Seems to be the trend. I have some (2x R24 kits) as well, but I'll likely never use them. The hype train seems to be losing steam.
 
Ontbijtkoek said:


Have you tried any of the other glp1s or did you go straight with tirzepatide?

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I've only used Tirz. Have Reta in the freezer just in case, but don't feel any need to break into it.
 
chewonmysac said:


Second thread in an hour that Reta is getting fried. Seems to be the trend. I have some (2x R24 kits) as well, but I'll likely never use them. The hype train seems to be losing steam.

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I'd put a dollar bet on Bunk Reta going around. I have 2 batches now that don't work well. The stuff I purchase from Peptidology remains effective, the others are less effective and/or completely ineffective. It seems Reta is not easy to make, there is always the chance the proteins get misfolded and it still tests fine.

In the trials, real Retatrutide has a 100% success rate.
 
cujet said:


I'd put a dollar bet on Bunk Reta going around. I have 2 batches now that don't work well. The stuff I purchase from Peptidology remains effective, the others are less effective and/or completely ineffective. It seems Reta is not easy to make, there is always the chance the proteins get misfolded and it still tests fine.

In the trials, real Retatrutide has a 100% success rate.

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Ive read good things about Peptidology but am I reading right that they are single vial? If so, wow, pretty $$.

I hadn't thought about the bad Reta and the increase in "it isn't working" being related, but you may be onto something.
 
I use Tirz and Reta. The thing that puzzles me are those users of Reta who complain of a lack of food noise suppression. If food noise suppression is most important, go with Tirz. I use both to keep titration lower and to get the benefits of Reta and Tirz together. It's an awesome combination.
 
cujet said:


I'd put a dollar bet on Bunk Reta going around. I have 2 batches now that don't work well. The stuff I purchase from Peptidology remains effective, the others are less effective and/or completely ineffective. It seems Reta is not easy to make, there is always the chance the proteins get misfolded and it still tests fine.

In the trials, real Retatrutide has a 100% success rate.

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Phase 3 results-Triumph-4



12.2% @9mg18.2% @12mg4.0% Placebo

Discontinued due to side effects
 
tirz cult member #3 here! i had great success with it. helped me for about 90lbs of my 135lbs weightloss. only tried 5mg for a couple months before losing insurance coverage and stopping before finding this place. back on 2.5 a week with 3,300mg in the freezer lol (my wife just started back on it too after childbirth so im building up the stockpile). ill be covered for a while and dont plan to ever come off just for the other benefits
 
chewonmysac said:


Phase 3 results-Triumph-4



12.2% @9mg18.2% @12mg4.0% Placebo

Discontinued due to side effects

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Yes, many people do have side effects, especially on higher doses. Those that stick with it do lose weight.
 
Ontbijtkoek said:


Seems like the response varies a lot depending on the individual, maybe due to some genetic polymorphisms.

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I just took my 7th (Tirz)shot. Like you, I have weight to lose and want to improve how I feel. In 6 weeks, in combo w improved eating habits (food choices) and exercise I have lost 10 lbs. I went from starting 2.5 for 4 weeks to 3 MG. I think Id like to stay LOW dose , and maybe add Reta (when I get it) on a low dose and see how they work in tandem with one another. By the time I get the reta (it was a group buy and they take longer) I may be at my goal, but we shall see. I have noticed Tirz has really helped with inflammation elsewhere in my body (fingers, knees, even my feet feel happier). Id start on low dose and maybe taper up SLOWLY to avoid the ugly side effects.
 
chewonmysac said:


Second thread in an hour that Reta is getting fried. Seems to be the trend. I have some (2x R24 kits) as well, but I'll likely never use them. The hype train seems to be losing steam.

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There is a huge divergence in experience on the forum side vs the clinical trails which is very wierd tbh.
 
cujet said:


I'd put a dollar bet on Bunk Reta going around. I have 2 batches now that don't work well. The stuff I purchase from Peptidology remains effective, the others are less effective and/or completely ineffective. It seems Reta is not easy to make, there is always the chance the proteins get misfolded and it still tests fine.

In the trials, real Retatrutide has a 100% success rate.

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I had mine group tested so this isn't an option. I even switched to a new vial, but it didn't change anything. Maybe there is somehow a unique difference in the generic version, but that would seem unlikely to me.
 
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