Tesa out the game? CBL-514 the new Tesa

Super Trips said:


CBL-514 is a novel injectable drug that may be safe and efficacious for localized abdominal subcutaneous fat reduction

Click to expand...
Click to expand...
Would love to see articles/links about this. Yes, I know Google exists, but I'd be more curious to see the things you've read about instead of Google's cold robot heart algorithm, haha.

Not sure Tesa/Egrifta is going away though. Looks like you said CBL-514 does its work on subcutaneous fat, Tesa drops the hammer on visceral fat. Not sure if combining them would have any high risks associated with it, but together, one could quickly look like a Fallout style Ghoul, I bet!
 
Super Trips said:


CBL-514 is a novel injectable drug that may be safe and efficacious for localized abdominal subcutaneous fat reduction

Click to expand...
Click to expand...

Can you elaborate on the safe part? The 3 sides I worry about with starting Tesa is edema and raising cortisol and prolactin.

The FDA are sure going to have their hands full when they get ready to ban all peptides because I am pretty sure they are going to have to do it one compound at a time. I don't think they can just blanket ban every compound on the planet or ever synthesized. I sure hope not. Science needs to invent thousands, maybe millions of new peptides with only enough changes in the structure to make it a unique compound, but with similar effects.

Should just take a few tech bro scientists with AI to start cranking out millions of new peptides every day and send these FDA luddites back to their cave.
 
Mr. Blonde said:


Is CBL-514 even available to buy yet? I obviously mean grey, not big pharma.

Click to expand...
Click to expand...

I just started researching it after reading this post. But I can just guess, if it is not, then it will be soon enough. I'm really interested in the safety profile if it is similar to the 'morelin' class type peptides.
 
Mr. Blonde said:


Is CBL-514 even available to buy yet? I obviously mean grey, not big pharma.

Click to expand...
Click to expand...
"It is a proprietary small-molecule drug currently in Phase 3 clinical trials and owned exclusively by Caliway Biopharmaceuticals, a publicly traded company based in Taiwan (TWSE: 6919)"

Close enough to our sources 😉
 
I'd have to do some digging so you'll just have to take my word for it but it's actually a proprietary formula using primarily Curcumin and resveratrol (maybe in a 4:1 ratio), no actual written formula exists, which is why I think it hasn't been made widely available in the grey market, at least one animal study suggests it might also somehow benefit visceral and hepatic fat, as well as some metabolic parameters, but what was most interesting to me - again, I'd have to dig this up. - one animal study suggested weight regain post GLP-1 was less when concurrently used with CBL-514. So yes, it seems to be effective and relatively safe on subcutaneous fat, but might have other application as well.

It's intriguing. It seems to be less harsh than some of the deoxyxcholate-based formulas, as well. I've done a little searching and haven't found the specific formula, or someone manufacturing, it anywhere.
 
From a quick look it is a localised fat reduction agent rather than for visceral fat, so quite different to tesa.

"CBL-514 (Caliway Biopharmaceuticals, New Taipei City, Taiwan) is a small-molecule injection lipolysis agent that promotes adipocyte apoptosis and targeted subcutaneous fat reduction in nonclinical studies without causing any skin necrosis, ulceration, nerve injury, and systemic side effects. "
 
Back
Top