Those combining Reta and Tirz

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anotherusername

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For those combining Retatrutide and Tirzepatide, how are you making sure in the higher doses that you don’t get too high a dose of GLP in total? It seems to me that the maximum combined dose should still be under 15mg since the max for tirz alone is 15, but is there less GLP specifically in Reta? Has anyone had experience running something like 12mg Retatrutide with 6-8mg tirzepatide for at least several months consecutively?
 
There are people on here taking high doses of you search a bit but just curious why you want to try this? Has your weight loss stalled?
 
anotherusername said:


For those combining Retatrutide and Tirzepatide, how are you making sure in the higher doses that you don’t get too high a dose of GLP in total? It seems to me that the maximum combined dose should still be under 15mg since the max for tirz alone is 15, but is there less GLP specifically in Reta? Has anyone had experience running something like 12mg Retatrutide with 6-8mg tirzepatide for at least several months consecutively?

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You're overthinking it with too little information to make meaningful conclusions ("It seems to me that the maximum combined dose should still be under 15mg"). Dose for efficacy, limited by sides.

I'm taking 18mg of Reta and .25mg of Sema weekly. It's working delightfully. I started on Tirz and moved to Reta, there was a period of overlap there a while back. My last dose of Tirz was on 3/12/26, 2.5mg, while taking 10-11mg of Reta.
 
I am on 15mg of tirz and 6 mg of reta - for about a year, plus more recently 0.5 of cagri. But I am using it to control severe lifelong obesity currently in remission at 55% body weight loss, way more than any of the studies have yet shown

The only really good reason for using combinations or higher total doses of GLP drugs is for severe obesity that does not get to normal or near normal weights with standard maximum doses and an adequate amount of time, at least a year. Almost certainly there are higher risks of both known side effects and possibly unknown side effects from doing this, but given the health risks of severe obesity are so terrible, it is unlikely those risks from the GLP's are higher than the risk of not treating the residual obesity. This approach has not been really studied yet except for the high dose semaglutide studies and the cagrisema studies, neither of which showed any new unexpected adverse effects, which is a bit reassuring but not proof it might not happen with other GLP's in combination, as tirz/reta/cagri are the three most commonly combined.

People do also use tirz/reta combinations to maximise the effects and reduce drug specific side effects, but usually this is done at doses below the maximum.

So in the end exceeding total recommended doses either from high doses of one drug or combinations is not really a problem, basically no one is actually going to do this unless higher doses are actually needed to control weight or hunger, and the only likely situation this is going to happen is in severe obesity or perhaps in a few percent who respond weakly to standard dose GLP's. Unfortunately there are limits to higher doses , where higher than standard maximum doses might cause less and less extra weight loss as doses go up, but side effects generally keep getting worse as doses go higher. The 16mg semaglutide study did show a few percent extra weight loss, but much higher side effect rates.
 
woundcarping said:


You're overthinking it with too little information to make meaningful conclusions ("It seems to me that the maximum combined dose should still be under 15mg"). Dose for efficacy, limited by sides.

I'm taking 18mg of Reta and .25mg of Sema weekly. It's working delightfully. I started on Tirz and moved to Reta, there was a period of overlap there a while back. My last dose of Tirz was on 3/12/26, 2.5mg, while taking 10-11mg of Reta.

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When you switched from Tirz to Reta did you start Reta at same mg or dose amount?
 
You only have so much GLP-1 receptors that can be agonized so increasing exposure to either one compound or multiple might not do anything on the GLP-1 side, but rather on the GIP or glucagon side.
 
Ontbijtkoek said:


You only have so much GLP-1 receptors that can be agonized so increasing exposure to either one compound or multiple might not do anything on the GLP-1 side, but rather on the GIP or glucagon side.

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I agree with this, it will also increase the risk of adverse side effects
 
I'm on tirz, 10mg split dosed...I'm going to start working in some reta in a couple 3 weeks, but I will go low to start and see how that goes. I don't think tirz and reta doses are equivalent 1:1, so I will find the reta dose where the symptoms kick in and baseline from there...
 
SecretMission said:


When you switched from Tirz to Reta did you start Reta at same mg or dose amount?

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woundcarping said:


I started Zep 12/12/25, I moved to compounded Tirz and was at 2.5mg 2x weekly until 1/10 when I moved to Reta. I took 7mg of Reta in total across 6 doses my first week. I've had 6 doses of Tirz since I started the bridge, totaling 14mg. I've had a total of 34 doses of Reta totaling 143mg. That averages 11.6mg/week with a chunk of that being getting my blood levels up using numerous small doses so I wouldn't overshoot and run into sides I had to wait out.

I moved to Reta for the GCGR signaling to boost BMR and presumptively spare lean mass better than Tirz.

GCGR signaling is dose dependent. Titrating Reta based on appetite/food noise is incorrect for reta, correct for Sema, Tirz, or Cagri. I titrated based on aversion to sides with the goal to get to or above 8mg/week levels for meaningful GCGR signaling.

I take Tirz PRN mainly to control food noise more so than hunger... my long term issue has been noise/brain side more than hunger/stomach side. I'll still take a bump if I expect the probability for trouble (like the 2.5mg dose in early March since I was traveling to either side of the country and back in 8 days).

Down 33lb since 1/10/25, 272lb to 239lb, practically all fat according to DEXA scans.

Had no meaningfully adverse sides.

Split dose, 2x weekly.

16mg/week with split dosing keeping my peaks only 15% higher than 12mg/once weekly (7mg 2x weekly has the same peaks).

RHR average hit a valley low of 58bpm on Tirz and is currently averaging 69-70bpm. This is inside my comfort level.

I don't expect 16mg to be magical over 12mg, but I do expect it to move my equilibrium point down ~10lb. That doesn't sound like much, but arguably that would be the hardest 10lb to lose. I chose to escalate my dose based on my sides and metrics including labs, fitness tracking, and sleep. I chose to do it now while I'm still resilient to the added stress vs later when systemic stress fatigue could be presenting.

Writing this post, I realized I failed to get labs on Lipase and Amylase to check my pancreas directly. My other labs suggest I'm doing fine, but gallstones/pancreatitis is my most likely hiccup. I'll get those labs drawn in the morning and report back if there's anything noteworthy.

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anotherusername said:


For those combining Retatrutide and Tirzepatide, how are you making sure in the higher doses that you don’t get too high a dose of GLP in total? It seems to me that the maximum combined dose should still be under 15mg since the max for tirz alone is 15, but is there less GLP specifically in Reta? Has anyone had experience running something like 12mg Retatrutide with 6-8mg tirzepatide for at least several months consecutively?

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6 mg reta and 8 tirz weekly for me.
 
Flash-BCR said:


I'm on tirz, 10mg split dosed...I'm going to start working in some reta in a couple 3 weeks, but I will go low to start and see how that goes. I don't think tirz and reta doses are equivalent 1:1, so I will find the reta dose where the symptoms kick in and baseline from there...

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Reta's glucagon doesn't start working until 4 mg dose. So under that it's basically tirz.

View: https://www.youtube.com/watch?v=oUL18iO18Oc&list=PLB_RSqpKtbEHo-3C3MCQTepuAIdG85KLs&index=111
 
CNCCurrency said:


Reta's glucagon doesn't start working until 4 mg dose. So under that it's basically tirz.

View: https://www.youtube.com/watch?v=oUL18iO18Oc&list=PLB_RSqpKtbEHo-3C3MCQTepuAIdG85KLs&index=111

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That's my thoughts as well, though I have seen push back here on the 4mg claim. I have a small pile of reta that I bought primarily for the glucagon fat burning component. I am getting close to goal weight, but like many, still have a little belly that won't go away...Hell, 10 years ago I did 1,000+ miles on the Appalachian Trail and got down to 170lbs by the time I was done...and in the last photo someone took of me, there was the little belly apron... 😎

I know that there is way more to addressing the fat than just reta, but I will start the resistance work and anything else I research...👍
 
Flash-BCR said:


That's my thoughts as well, though I have seen push back here on the 4mg claim. I have a small pile of reta that I bought primarily for the glucagon fat burning component. I am getting close to goal weight, but like many, still have a little belly that won't go away...Hell, 10 years ago I did 1,000+ miles on the Appalachian Trail and got down to 170lbs by the time I was done...and in the last photo someone took of me, there was the little belly apron... 😎

I know that there is way more to addressing the fat than just reta, but I will start the resistance work and anything else I research...👍

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In the video he addresses that, he says the clinical trial studies shows it to be true, So?
 
CNCCurrency said:


In the video he addresses that, he says the clinical trial studies shows it to be true, So?

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yeah....I'm pretty much a believer in the 4mg and want to get to the 4mg as quickly as I can. I have plenty of slack to give up with the tirz at 10mg by titrating down that if the reta sides aren't too bad, I will just add reta to a proper dose....I'll split dose the tirz and reta and then go from there. I have plenty of both that I can go years on with just one or the other....or both... 👍
 
Flash-BCR said:


That's my thoughts as well, though I have seen push back here on the 4mg claim. I have a small pile of reta that I bought primarily for the glucagon fat burning component. I am getting close to goal weight, but like many, still have a little belly that won't go away...Hell, 10 years ago I did 1,000+ miles on the Appalachian Trail and got down to 170lbs by the time I was done...and in the last photo someone took of me, there was the little belly apron... 😎

I know that there is way more to addressing the fat than just reta, but I will start the resistance work and anything else I research...👍

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1,000+ miles ON THE APPALACHIAN TRAIL?!?

What a blessing sir. Like omg. In one go?!

I go trailing a lot, and when I tell my family “chat later I’m going on a trail” they find it impressive and shocking that I do 5 mile walks every other day. You would SCALP them with your numbers! Sheeeshhh
 
"People do also use tirz/reta combinations to maximise the effects and reduce drug specific side effects, but usually this is done at doses below the maximum."

Or, in my case, 'cause I labratted meself to see if there were any additional benefits.

There weren't. YMMV
 
PunctiliousKitten said:


1,000+ miles ON THE APPALACHIAN TRAIL?!?

What a blessing sir. Like omg. In one go?!

I go trailing a lot, and when I tell my family “chat later I’m going on a trail” they find it impressive and shocking that I do 5 mile walks every other day. You would SCALP them with your numbers! Sheeeshhh

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There is lots of hiking in Arizona and its always been one of my passions....in the 90's when I was younger and more fit, and more brave, I would train for a few months and then go do the Grand Canyon Rim to Rim to Rim...42 miles with 12,000+ft of elevation gain. I would do it in under 11 hrs all in daylight...

So, I did a lot of that, but never did backpack hiking, so at 59 years old, I thought I better do it now, or at some point my body, or my doctor is going to tell me I can't do it...so off I went...2 1/2 months worth... 👍
 
JoonyO said:


"People do also use tirz/reta combinations to maximise the effects and reduce drug specific side effects, but usually this is done at doses below the maximum."

Or, in my case, 'cause I labratted meself to see if there were any additional benefits.

There weren't. YMMV

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Indeed! Because for me there have been the additional benefits. It really can be beneficial sometimes to be your own researcher and subject, even if one thing is meh, there are other options coming on line every couple months to try out.
 
Flash-BCR said:


There is lots of hiking in Arizona and its always been one of my passions....in the 90's when I was younger and more fit, and more brave, I would train for a few months and then go do the Grand Canyon Rim to Rim to Rim...42 miles with 12,000+ft of elevation gain. I would do it in under 11 hrs all in daylight...

So, I did a lot of that, but never did backpack hiking, so at 59 years old, I thought I better do it now, or at some point my body, or my doctor is going to tell me I can't do it...so off I went...2 1/2 months worth... 👍

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Bravo young man! 🥂🫂 I want to be like you
 
I have been taking Triz & ordered Reta thinking it helped with the food noise more. I guess I'll see after trying the Reta because I still have ridiculous food noise. Thanks for the info!
 
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