Tirz experience = Reta experience?

AngieHolmes said:


There is no "brand name" Reta yet . . .

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If you’re in the trials or the new expanded access program and getting it from Lilly, Lilly would be a brand name. The drug itself doesn’t have a brand name yet though.
 
unclebuff702 said:


Same.

I thought I was going to die on Sema. Turns out, the doctor (actual MD, not a health spa lol) I got the RX from started me at 2.4mg. Two years later when I started researching other options I found out that apparently the doctor a) wanted me to die, b) was super ignorant or negligent, or 3) thought I was fat enough to warrant going straight to the end zone lol.

So, I could be biased thinking sema hit different, but I've had almost zero sides on Tirz or Reta, and I'd rather stick a fork in an electric socket than feel the way I felt on my very first dose Sema.

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Sure you were nervous about starting others with how bad that must have been. Luckily it didn't put you off trying any altogether 🙁
 
I am so fixated on the new name part that I can't concentrate on the side effects.

AngieHolmes said:


There is no "brand name" Reta yet . . .

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I am stuck and just can not decide this.

Should brand reta be named Xyzolvify or Jentamub ? /lol
 
Just A Cat said:


I am so fixated on the new name part that I can't concentrate on the side effects.

I am stuck and just can not decide this.

Should brand reta be named Xyzolvify or Jentamub ? /lol

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Maybe they'll have a contest! I saw some possible names Lilly was tossing out but AFAIK they haven't settled on one yet . . .
 
Speedy said:


Only been on brand name, Tirz and Reta. Different side effects from Reta and Tirz. Tirz sides obviously same as brand name M.

Could not tolerate Reta. Low bp normally now and Reta drove it down even further making me feel like crap.

Anyhoo. Looking for the supposedly hilarious ghk-cu topic if anyone wants to shoot me a link.

Also since I lurk trying to see if after a few years I graduated from being a newbie here.

—still a newbie

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interesting - Im usually lowish BP - like 100-110/60. I wonder if reta would make that lower, never heard of that happening
 
bamagirl26 said:


interesting - Im usually lowish BP - like 100-110/60. I wonder if reta would make that lower, never heard of that happening

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GLP1 drugs and weight loss in general typically reduce blood pressure.
 
woundcarping said:


GLP1 drugs and weight loss in general typically reduce blood pressure.

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Thanks,will keep an eye on it. I assumed the lowered bp was from significant weight loss (which is from the medicine obvi, but I didnt realize the medicine itself would lower bp).
 
Flash-BCR said:


Oh man...another poster parachuting into the site from out of nowhere and lashing out...."find a community?"...the community already exists. I think your expectation is that this 'community' needs to change/bend to your vision...When I read the poster's post that you were responding to, it made a lot sense to me...

Only thing I got out of your post was, you should "take your own advice and quit coming off as arrogant and rude for no good reason"...

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I added them to my ignore list.
 
spanky2026 said:


Just curious about something I keep reading that I assume is anecdotal, have no idea how real it is among users:

I often see people saying I had zero side effects on (insert Tirz or Reta) and when I added in or changed to (the other) I also had zero side effects. Yes, of course, we're all different etc, but I'm curious if zero ill effects on one is at least a semi-reliable indicator of how you may react to the other?

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bamagirl26 said:


interesting - Im usually lowish BP - like 100-110/60. I wonder if reta would make that lower, never heard of that happening

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Me neither -- but my normally low BP has bottomed out the past few weeks and it's a true bummer. Gonna skip reta this week and see if it improves.
 
bamagirl26 said:


interesting - Im usually lowish BP - like 100-110/60. I wonder if reta would make that lower, never heard of that happening

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I’d probably steer away from reta with a BP like that. I’d anticipate that it’s likely to cause symptomatic hypotension (at the least orthostatic hypotension). But your blood pressure itself is unlikely to drop much from there as your body will crank your heart rate to prevent that from happening. I would anticipate a large heart rate increase instead.
 
SapphireGlitch60 said:


I am also curious about this. I had zero sides on sema, maxed that out and moved to a mid-dose of tirz and zero sides on that as well. I’ve been on tirz 15mg for 18mos and really want to switch to reta to see if I can get to goal (30 more lbs, 78 total lost so far). I’m a little worried about new sides, but more than that - I’m REALLY worried I won’t respond to it. I lost 50 on sema and 28 on tirz over 28 mos and while I realize this is a slow game and am happy to play, I don’t want to make it any slower than it already is!

Trying to figure out how to make the transition. I was planning on quitting tirz cold turkey and going to 2mg reta, but I’m worried it won’t work and I’ll gain a bunch of weight back.

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There really is no clunkier way to make that transition than cold turkeying 15mg of tirz and jumping in at the starting dose of reta. It will feel about as effective as switching to 2.5mg of tirz. You’re talking about spending months at doses where you will be struggling and very likely gaining weight until you can get into the 9-12mg range, and even then a lot of people who make this transition seem to still struggle with the feel even if it does break their plateau.

I’ve never used tirz but I see the most success in people approaching this transition by gradual titrating down on their tirz dose as they increase their reta dose. Try to keep the combined total at 100% of a full dose. That generally seems to be the most pain and setback free way to tackle this.
 
SapphireGlitch60 said:


I am also curious about this. I had zero sides on sema, maxed that out and moved to a mid-dose of tirz and zero sides on that as well. I’ve been on tirz 15mg for 18mos and really want to switch to reta to see if I can get to goal (30 more lbs, 78 total lost so far). I’m a little worried about new sides, but more than that - I’m REALLY worried I won’t respond to it. I lost 50 on sema and 28 on tirz over 28 mos and while I realize this is a slow game and am happy to play, I don’t want to make it any slower than it already is!

Trying to figure out how to make the transition. I was planning on quitting tirz cold turkey and going to 2mg reta, but I’m worried it won’t work and I’ll gain a bunch of weight back.

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I went from 5mg of Tirz to 16mg of Reta in under 14 weeks with negligible adverse sides. I've gone as high as 20mg/week. I started the bridge on 1/10 and am down 73lb since then, 83lb overall. I still have ~20lb to go.

My methodology was to take numerous small doses watching for sides as I moved up. The idea behind small doses was if I overshot my tolerance, I wouldn't have to wait long for the sides to wane.

Here's an older post with more details:

woundcarping said:


Everyone has their own thoughts, here's my observations/experiences:

What was your Tirz dose?

I started Zep 12/12/25, I moved to compounded Tirz and was at 2.5mg 2x weekly until 1/10 when I moved to Reta. I took 7mg of Reta in total across 6 doses my first week. I've had 6 doses of Tirz since I started the bridge, totaling 14mg. I've had a total of 34 doses of Reta totaling 143mg. That averages 11.6mg/week with a chunk of that being getting my blood levels up using numerous small doses so I wouldn't overshoot and run into sides I had to wait out.

I moved to Reta for the GCGR signaling to boost BMR and presumptively spare lean mass better than Tirz.

GCGR signaling is dose dependent. Titrating Reta based on appetite/food noise is incorrect for reta, correct for Sema, Tirz, or Cagri. I titrated based on aversion to sides with the goal to get to or above 8mg/week levels for meaningful GCGR signaling.

I take Tirz PRN mainly to control food noise more so than hunger... my long term issue has been noise/brain side more than hunger/stomach side. I'll still take a bump if I expect the probability for trouble (like the 2.5mg dose in early March since I was traveling to either side of the country and back in 8 days).

Down 33lb since 1/10/25, 272lb to 239lb, practically all fat according to DEXA scans.

Had no meaningfully adverse sides.

Split dose, 2x weekly.

16mg/week with split dosing keeping my peaks only 15% higher than 12mg/once weekly (7mg 2x weekly has the same peaks).

RHR average hit a valley low of 58bpm on Tirz and is currently averaging 69-70bpm. This is inside my comfort level.

I don't expect 16mg to be magical over 12mg, but I do expect it to move my equilibrium point down ~10lb. That doesn't sound like much, but arguably that would be the hardest 10lb to lose. I chose to escalate my dose based on my sides and metrics including labs, fitness tracking, and sleep. I chose to do it now while I'm still resilient to the added stress vs later when systemic stress fatigue could be presenting.

Writing this post, I realized I failed to get labs on Lipase and Amylase to check my pancreas directly. My other labs suggest I'm doing fine, but gallstones/pancreatitis is my most likely hiccup. I'll get those labs drawn in the morning and report back if there's anything noteworthy.

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AngieHolmes said:


There is no "brand name" Reta yet . . .

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Brand name Tirz., grey Tirz and grey Reta.

Sorry, though it was clear what I meant, but apparently it needed to be clearly written out.
 
bamagirl26 said:


interesting - Im usually lowish BP - like 100-110/60. I wonder if reta would make that lower, never heard of that happening

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Mine is normally 90/60. On Reta it was 80/40 when I was feeling good. Didn’t test when I was symptomatic so not sure how low it went.

Still a newbie. 15 min delay.
 
It was the comma after name and before tirz and Reta. It caused both of those now to be a grouping and the “brand name” to refer to both of them. I’m not trying to be pedantic so much as simply clarifying from where the confusion came. This specifically is not a case so much but we are dealing with injectable substances and clarity quite often matters. All’s well

Speedy said:


Brand name Tirz., grey Tirz and grey Reta.

Sorry, though it was clear what I meant, but apparently it needed to be clearly written out.

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Elgordoboy said:


It was the comma after name and before tirz and Reta. It caused both of those now to be a grouping and the “brand name” to refer to both of them. I’m not trying to be pedantic so much as simply clarifying from where the confusion came. This specifically is not a case so much but we are dealing with injectable substances and clarity quite often matters. All’s well

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So lack of the Oxford comma strikes again.
 
Speedy said:


So lack of the Oxford comma strikes again.

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Hilarious! I didn’t realize you meant three different substances. I thought you’d just unnecessarily used the comma at all in describing just two. Yes the Oxford comma would’ve bailed that out. Good one
 
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