Weight Gain, and new plan. Looking for ideas and stories.

TheAnonOne

TheAnonOne

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Hello, new here but not to grey or GLPs

THE HISTORY:

I have been on Tirz for nearly 3 years now and went from 270->220. Big win. Switched to Reta lost another 10(ish), another big win. Never really hit my goals of being in the 190s as a 6ft tall male though but, I'll take it.

So Reta is the king, or so I thought. I really kinda equalized on Reta at 215(ish) which, more or less was matching Tirz.

Fast forward about a year or so, I had to go back to only Tirz due to "Anhedonia" or a general "bla". I am normally a very upbeat positive person but on high levels of Reta it's just not fun generally.

I regained about 10-15lbs and exist somewhere in the 225->230 range. I feel it, it needs to change.

I've been on 10mg of Tirz /w for most of 2026 now.

THE PLAN:

As far as GLP-1s go, my options feel a bit limited. My thought is that Reta itself WOULD or COULD get me back to where I was and possibly where I want to be but, I can't go straight, high-dose Reta again due to Anhedonia.

My plan is to possibly go 15+mg of Tirz AND add in very low 1-2mg/w doses of Reta.

Has anyone been in this situation? Any success? Mostly just looking for ideas and stories on what has worked. Obviously diet/exercise are a component, but that's another topic for another forum I think.
 
woundcarping said:


Where did your Tirz and Reta doses get to before?

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Click to expand...

So, I've been to max dosing in both, not for extreme prolonged time periods, but I have been. Not at the same time obviously.
 
TheAnonOne said:


Hello, new here but not to grey or GLPs

THE HISTORY:

I have been on Tirz for nearly 3 years now and went from 270->220. Big win. Switched to Reta lost another 10(ish), another big win. Never really hit my goals of being in the 190s as a 6ft tall male though but, I'll take it.

So Reta is the king, or so I thought. I really kinda equalized on Reta at 215(ish) which, more or less was matching Tirz.

Fast forward about a year or so, I had to go back to only Tirz due to "Anhedonia" or a general "bla". I am normally a very upbeat positive person but on high levels of Reta it's just not fun generally.

I regained about 10-15lbs and exist somewhere in the 225->230 range. I feel it, it needs to change.

I've been on 10mg of Tirz /w for most of 2026 now.

THE PLAN:

As far as GLP-1s go, my options feel a bit limited. My thought is that Reta itself WOULD or COULD get me back to where I was and possibly where I want to be but, I can't go straight, high-dose Reta again due to Anhedonia.

My plan is to possibly go 15+mg of Tirz AND add in very low 1-2mg/w doses of Reta.

Has anyone been in this situation? Any success? Mostly just looking for ideas and stories on what has worked. Obviously diet/exercise are a component, but that's another topic for another forum I think.

Click to expand...
Click to expand...
I take 8 mg tirrz and 7 mg reta for over a year now. Works for me. As they say mileage may vary.
 
TheAnonOne said:


Hello, new here but not to grey or GLPs

THE HISTORY:

I have been on Tirz for nearly 3 years now and went from 270->220. Big win. Switched to Reta lost another 10(ish), another big win. Never really hit my goals of being in the 190s as a 6ft tall male though but, I'll take it.

So Reta is the king, or so I thought. I really kinda equalized on Reta at 215(ish) which, more or less was matching Tirz.

Fast forward about a year or so, I had to go back to only Tirz due to "Anhedonia" or a general "bla". I am normally a very upbeat positive person but on high levels of Reta it's just not fun generally.

I regained about 10-15lbs and exist somewhere in the 225->230 range. I feel it, it needs to change.

I've been on 10mg of Tirz /w for most of 2026 now.

THE PLAN:

As far as GLP-1s go, my options feel a bit limited. My thought is that Reta itself WOULD or COULD get me back to where I was and possibly where I want to be but, I can't go straight, high-dose Reta again due to Anhedonia.

My plan is to possibly go 15+mg of Tirz AND add in very low 1-2mg/w doses of Reta.

Has anyone been in this situation? Any success? Mostly just looking for ideas and stories on what has worked. Obviously diet/exercise are a component, but that's another topic for another forum I think.

Click to expand...
Click to expand...
I stacked tirz and reta to break a tirz stall. Since I started tirz, I've never stopped taking it. I just added reta while I dialed back on tirz. The combo worked for that plateau. I've been on 10mg reta for several months now and I look forward to being able to find a new balance for maintenance. I'm starting to be aware of the 'bla' and it's much worse than it sounds.
 
What is the situation outside of the GLPs? Are you focusing on caloric intake/protein/exercise/sleep? Optimizing or improving any of those, if not already optimized, might be a huge catalyst for movement.
 
Romulusguy said:


What is the situation outside of the GLPs? Are you focusing on caloric intake/protein/exercise/sleep? Optimizing or improving any of those, if not already optimized, might be a huge catalyst for movement.

Click to expand...
Click to expand...
Of course, I do a 4mile hike 3, sometimes 4 times weekly and light strength training. The diet is one of those on-point things 4 days a week and suffers on weekends. Friends have events etc.

Obviously GLPs vastly improve the diet side of things. Or at least "DID" at the beginning, and probably still do but, it's been so long now its just a new baseline/normal.

As much as I appreciate the diet/exercise chat, now in my mid 30s, I've had it 10,000 times, personal trainers, etc. Nothing has worked like GLP-1s. Even in this kinda... "lame non-working" state it's more successful than hitting the gym with an actual trainer was for me, in my 20s.

Those items are going to get handled, or improved on, but my specific questions are around GLP-1 stacking and if it's worked or not.

-Has going over 15mg with tirz actually been useful?

-Has very low levels of Reta been useful?
 
TheAnonOne said:


Of course, I do a 4mile hike 3, sometimes 4 times weekly and light strength training. The diet is one of those on-point things 4 days a week and suffers on weekends. Friends have events etc.

Obviously GLPs vastly improve the diet side of things. Or at least "DID" at the beginning, and probably still do but, it's been so long now its just a new baseline/normal.

As much as I appreciate the diet/exercise chat, now in my mid 30s, I've had it 10,000 times, personal trainers, etc. Nothing has worked like GLP-1s. Even in this kinda... "lame non-working" state it's more successful than hitting the gym with an actual trainer was for me, in my 20s.

Those items are going to get handled, or improved on, but my specific questions are around GLP-1 stacking and if it's worked or not.

-Has going over 15mg with tirz actually been useful?

-Has very low levels of Reta been useful?

Click to expand...
Click to expand...
Completely understand. Asking about diet/etc. is kind of like asking a person if they have restarted their computer when working in tech support: it must be asked 😛
 
TheAnonOne said:


The diet is one of those on-point things 4 days a week and suffers on weekends

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Daily caloric deficit is not as important as weekly average.

You target 3500 less than your BMR per week to lose 1lb

GLP1s make it much easier, but it is certainly possible to eat when you are not hungry or eat very high calorie foods.

The peptides lie to your brain and say you feel full, but you can always argue with them and keep going.

TheAnonOne said:


-Has going over 15mg with tirz actually been useful?

-Has very low levels of Reta been useful?

Click to expand...
Click to expand...
Many people have gone over 15mg and seen some benefit, there are currently trials that start at 25mg.

The previous trials showed diminishing returns on higher doses.

Adding Reta could help as it hits a 3rd receptor; glucagon and also would stack on the Tirz GLP1 and GIP

Glucagon receptor component: Mimics glucagon to boost calorie burning (energy expenditure) and break down fat tissue and liver fat.
 
TheAnonOne said:


Of course, I do a 4mile hike 3, sometimes 4 times weekly and light strength training. The diet is one of those on-point things 4 days a week and suffers on weekends. Friends have events etc.

Obviously GLPs vastly improve the diet side of things. Or at least "DID" at the beginning, and probably still do but, it's been so long now its just a new baseline/normal.

As much as I appreciate the diet/exercise chat, now in my mid 30s, I've had it 10,000 times, personal trainers, etc. Nothing has worked like GLP-1s. Even in this kinda... "lame non-working" state it's more successful than hitting the gym with an actual trainer was for me, in my 20s.

Those items are going to get handled, or improved on, but my specific questions are around GLP-1 stacking and if it's worked or not.

-Has going over 15mg with tirz actually been useful?

-Has very low levels of Reta been useful?

Click to expand...
Click to expand...
Here's a question...

What day is your shot day? Might it be Sunday, Monday or Tuesday?

Yes you might have events and stuff like that on the weekend, but if you're not doing it already, you might want to think about taking your shot on Thursday so you can maximize the appetite suppression effect on the weekend.
 
Oh and if you wonder if there are people exceeding 15mg a week and living to tell about it, I give you this thread:




High doses of Tirz updates 60mg a week



So I would like to update my 60mg a week tirz exp. yes im still alive and still researching my dose is 20-25mg of tirz every 2 days with a stack of 2.5 or 5mg sema with that dose 6mg of survo 6mg of elro 2.5-5mg cagri 6mg of reta now these were not combined but at different weeks i tried a new...

051f0e2f5b7f6ffbb4a2f10b404546ba44b6197464dfbacec1b043fb189c69a3.png



GLP1Chat.com
 
Spork said:


Here's a question...

What day is your shot day? Might it be Sunday, Monday or Tuesday?

Yes you might have events and stuff like that on the weekend, but if you're not doing it already, you might want to think about taking your shot on Thursday so you can maximize the appetite suppression effect on the weekend.

Click to expand...
Click to expand...
This is a great point, I purposely chose Wednesday so my 6th and 7th would be Mon,Tue
 
AllCourtTENNIS said:


I stacked tirz and reta to break a tirz stall. Since I started tirz, I've never stopped taking it. I just added reta while I dialed back on tirz. The combo worked for that plateau. I've been on 10mg reta for several months now and I look forward to being able to find a new balance for maintenance. I'm starting to be aware of the 'bla' and it's much worse than it sounds.

Click to expand...
Click to expand...
Yes, the "bla" is really making it sound just kind of benign or whatever. It's incredibly debilitating and has actually given me quite a bit more empathy for people who deal with real "depression" or similar situations. I absolutely could NOT exist like that for more than a few weeks. It's truly awful.

I actually went onto Reta twice, and both times hit it. That said it seems like maybe it only hits me at 6mg+ weekly. So I am willing to try again but, using a blend to keep Reta down.

(also the time limits on 'reply' for me is currently half an hour, I somewhat get why this forum has those but it's quite the detractor from keeping a conversation going currently)

Romulusguy said:


Completely understand. Asking about diet/etc. is kind of like asking a person if they have restarted their computer when working in tech support: it must be asked 😛

Click to expand...
Click to expand...
For sure, I won't act like I have the best diet OR exercise plan, I don't, its CLEARLY not ideal or I would have abs and not trying GLP-1s as a booster at all haha
 
Spork said:


Oh and if you wonder if there are people exceeding 15mg a week and living to tell about it, I give you this thread:




High doses of Tirz updates 60mg a week



So I would like to update my 60mg a week tirz exp. yes im still alive and still researching my dose is 20-25mg of tirz every 2 days with a stack of 2.5 or 5mg sema with that dose 6mg of survo 6mg of elro 2.5-5mg cagri 6mg of reta now these were not combined but at different weeks i tried a new...

051f0e2f5b7f6ffbb4a2f10b404546ba44b6197464dfbacec1b043fb189c69a3.png



GLP1Chat.com

Click to expand...
Click to expand...

Saw that before I had an account. I wasn't actually worried about the health risks. Tirz and I seem to get along together well. I've never had a really negative side effect other than maybe some tiredness the day after injection.

Wild run though, 60mg per week is something.
 
TheAnonOne said:


My plan is to possibly go 15+mg of Tirz AND add in very low 1-2mg/w doses of Reta.

Click to expand...
Click to expand...
I’m 13.2mg Tz on Mondays and 3mg R on Thursday,

The small dose of Reta helps keep my metabolism moving l, was higher and came back down; Anhedonia, RHR, skin sensitivity (thought it was anaphylaxis). Like the effects of Reta however not the sides.

Tried both alone and I perfer the Tirz but I wanted the higher metabolic rate from Reta. I find that 3mg of Reta is the sweet spot for me now.

I am planning to titrate up to 15mg T in 10 days.
 
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