Elora way better for me than Cagri šŸ‘šŸ»

lessthanhalf said:


Thank you for useful real world practical experience with it. It is hard to guess what side effects might be like with it as rates seem very low at low doses but not low at all at doses higher than 3mg. I also noticed the rats basically stopped eating for a week when it was added to tirz.

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I'm hoping that I don't have to go much over the 3mg. I struggled to compute the equivalent human doses from the rat study, but I think it was the max dose equivalents of both tirz and Elora,. If so, I understand why the rats didn't eat for a week....Even on these low doses, I have not much interest in eating.
 
There's only one vendor who has paid for and posted full tests so far, according to Jano.

3 different COAs, one with structure.

Looks like it took one extra month to get the structural analysis with full report.

Image result in www.google.com/search?q=+peptides+eloralintide+bridge+expected

The results are public on their website, but you have to register.

It costs about the price of a kit for one vial.
 
RadicalCrimson said:


I started at 3mg (Uther) coming from months at 2.4mg cagri, and it's been slowly ramping up, doing well after 3 weeks, 4th dose today.

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What made you decide to switch from cagri?
 
Grogu said:


What made you decide to switch from cagri?

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I also have the same question. Because the current price is about 170 USD for 10x 5mg Vials. This is expensive. When you need 3mg per pin, that's 15 USD. It's insane. Whereas you use just 25 mcg of Cagri. So even a 5mg vial last a long time.
 
Kyli said:


I also have the same question. Because the current price is about 170 USD for 10x 5mg Vials. This is expensive. When you need 3mg per pin, that's 15 USD. It's insane. Whereas you use just 25 mcg of Cagri. So even a 5mg vial last a long time.

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Yes, cagri is pretty inexpensive compared to elora, but I think you meant 250 mcg, right? 25 mcg would be a pretty small dose.

As far as Elora, to me it's about early access as the cost will likely go down, if (and when), more sources are able to reliably produce the product. It will happen, it's just a matter of how long it will take. But even with the current high prices, it's still "better" than anything we'd ever see in the pharma space or even compound. So to me, to have early access to this new medication is pretty cool.
 
Grogu said:


Yes, cagri is pretty inexpensive compared to elora, but I think you meant 250 mcg, right? 25 mcg would be a pretty small dose.

As far as Elora, to me it's about early access as the cost will likely go down, if (and when), more sources are able to reliably produce the product. It will happen, it's just a matter of how long it will take. But even with the current high prices, it's still "better" than anything we'd ever see in the pharma space or even compound. So to me, to have early access to this new medication is pretty cool.

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Don't Cagri and Elora function in very similar ways?
 
spanky2026 said:


Don't Cagri and Elora function in very similar ways?

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Eloralintide was designed to be more targeted and to elicit fewer side effects. They are both amylin agonists.
 
spanky2026 said:


Don't Cagri and Elora function in very similar ways?

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What @Spork said and I would add that eloralintide also has a substantially longer half-life than cagri.

Cagrilintideā€™s reported half-life is about 7ā€“8 days, with peak concentrations occurring one to three days after injection. Eloralintideā€™s half-life is closer to two weeks, and it may not reach peak concentrations until approximately three to five-and-a-half days after injection.

This longer half-life means that eloralintide should theoretically produce a flatter weekly concentration curve, more accumulation from one weekly dose to the next, a slower apparent onset, and a substantially slower washout after stopping. The more targeted AMY-1 activation and the relatively stable concentrations are most likely why eloralintide may have less side effects than cagrilinitide. Finally, elora is a much more complex molecule than cagri, which makes the peptide more difficult to manufacture.
 
Grogu said:


What @Spork said and I would add that eloralintide also has a substantially longer half-life than cagri.

Cagrilintideā€™s reported half-life is about 7ā€“8 days, with peak concentrations occurring one to three days after injection. Eloralintideā€™s half-life is closer to two weeks, and it may not reach peak concentrations until approximately three to five-and-a-half days after injection.

This longer half-life means that eloralintide should theoretically produce a flatter weekly concentration curve, more accumulation from one weekly dose to the next, a slower apparent onset, and a substantially slower washout after stopping. The more targeted AMY-1 activation and the relatively stable concentrations are most likely why eloralintide may have less side effects than cagrilinitide. Finally, elora is a much more complex molecule than cagri, which makes the peptide more difficult to manufacture.

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Interesting. I had enough of an allergic reaction to Cagri (not anaphylaxis but obvious allergic reaction x2 ) that Elora also gives me pause now, but I'm still intrigued.
 
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